Iron and nitrogen-co-doped carbon quantum dots for the sensitive and selective detection of hematin and ferric ions and cell imaging
| Autor: | Li Li, Zheng Hou, Mingfeng Ge, Wen-Fei Dong, Yuqing Wu, Minghui Zan, Lei Cao |
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| Rok vydání: | 2021 |
| Předmět: |
Nitrogen
Iron chemistry.chemical_element Quantum yield 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Analytical Chemistry chemistry.chemical_compound Quantum Dots Electrochemistry medicine Humans Environmental Chemistry Solubility Spectroscopy Fluorescent Dyes Ions Detection limit 021001 nanoscience & nanotechnology Fluorescence Carbon 0104 chemical sciences chemistry Hemin Ferric 0210 nano-technology Selectivity HeLa Cells medicine.drug Nuclear chemistry |
| Zdroj: | The Analyst. 146:4954-4963 |
| ISSN: | 1364-5528 0003-2654 |
| Popis: | Iron, nitrogen-co-doped carbon quantum dots (Fe,N-CDs) were prepared via a simple one-step hydrothermal method. The quantum yield of fluorescence reached about 27.6% and the blue-emissive Fe,N-CDs had a mean size of 3.76 nm. The as-prepared carbon quantum dots showed good solubility, a high quantum yield, good biocompatibility, low cytotoxicity, and high photostability. Interestingly, the as-prepared Fe,N-CDs exhibited good selectivity and sensitivity toward both hematin and ferric ions, and the limit of detection for hematin and ferric ions was calculated to be about 0.024 μM and 0.64 μM, respectively. At the same time, Fe,N-CDs were used for imaging HeLa cells and showed that most Fe,N-CDs were detained in the lysosome. Thus, this fluorescent probe has potential application in the quantitative detection of hematin or Fe3+ in a complex environment and for determining Fe3+ at the cellular level. |
| Databáze: | OpenAIRE |
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