Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder
| Autor: | Tahiana Andreazza, Mariana Pedrini, Clarissa Severino Gama, Esalba Silveira, Márcia Kauer-Sant'Anna, Jaqueline Salvador, Paulo Belmonte-de-Abreu, Anna-Martha V. Fontanari, Pamela Ferrari, Walter Jose Koff, Bianca Wollenhaupt de Aguiar, Maria Inês Rodrigues Lobato, Ângelo Brandelli Costa, Flávio Kapczinski, Raffael Massuda |
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| Rok vydání: | 2012 |
| Předmět: |
Brain-derived neurotrophic factor
Adult Male Psychiatric Status Rating Scales Gender Identity Disorder medicine.medical_specialty Brain-Derived Neurotrophic Factor Gender Identity Pathogenesis Psychiatry and Mental health Young Adult Endocrinology Neurotrophic factors Internal medicine Neuroplasticity medicine Humans In patient Female Young adult Psychology Psychological abuse Biological Psychiatry Transsexualism Clinical psychology |
| Zdroj: | Journal of psychiatric research. 47(10) |
| ISSN: | 1879-1379 |
| Popis: | Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis of psychiatric disordersand is related to traumatic life events. To examine serum BDNF levels, we compared one group of DSM-IV GID patients (n = 45) and one healthy control group (n = 66). Serum BDNF levels were significantly decreased in GID patients (p = 0.013). This data support the hypothesis that the reduction found in serum BDNF levels in GID patients may be related to the psychological abuse that transsexuals are exposed during their life. |
| Databáze: | OpenAIRE |
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