Evaluation of tissue hemoglobin saturation (StO 2 ) using near-infrared spectroscopy during hypoxemia and hyperoxemia in Beagle dogs
| Autor: | Stephen R. Werre, Carolina H Riccó, Maria Killos, Natalia Henao-Guerrero, Noah D. Pavlisko |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Cardiac output 040301 veterinary sciences medicine.medical_treatment Cardiac index Hyperoxia Hypoxemia 0403 veterinary science Hemoglobins 03 medical and health sciences Dogs 0302 clinical medicine Heart rate medicine Animals Dog Diseases Hypoxia Monitoring Physiologic Mechanical ventilation Spectroscopy Near-Infrared General Veterinary business.industry Hyperoxemia 030208 emergency & critical care medicine 04 agricultural and veterinary sciences Esmolol Oxygen Isoflurane Anesthesia Female medicine.symptom business medicine.drug |
| Zdroj: | Veterinary Anaesthesia and Analgesia. 43:18-26 |
| ISSN: | 1467-2987 |
| DOI: | 10.1111/vaa.12258 |
| Popis: | Objective To determine the relationship between tissue oxygen saturation (StO 2 ) and oxygen delivery ( D . O 2 ) during hypoxemia and hyperoxemia. Study design Prospective, randomized study. Animals Eight purpose-bred Beagle dogs. Methods Dogs were anesthetized with isoflurane, ventilated to eucapnia, and instrumented for thermodilution cardiac output, invasive mean arterial pressure (MAP), sartorius muscle StO 2 and airway gas monitoring. Dogs were administered rocuronium to facilitate mechanical ventilation and esmolol to minimize anesthetic effects on cardiac output. Instrumentation and baseline data collection were at 0.21 fractional inspired oxygen (FIO 2 ). Dogs were evaluated at high (0.40 then 0.95) and low (0.15 then 0.10) FIO 2 sequences in random order with a 60 minute rest period at FIO 2 0.21 between sequences. Target FIO 2 was achieved by manipulating nitrogen and oxygen flow rates. Data collected at each FIO 2 , after a 10 minute period of stabilization, included heart rate (HR), MAP, cardiac index (CI) and StO 2 . Arterial oxygen content (CaO 2 ) and oxygen delivery index ( D . O 2 I ) were calculated at each FIO 2 . Data analysis included Pearson’s correlation analysis and mixed-model anova ( p Results There were no significant differences in HR, MAP or CI across all FIO 2 values. Significant decreases occurred in mean ± standard deviation StO 2 (90 ± 4% to 69 ± 18%; p = 0.0001), D . O 2 I (458 ± 70 to 281 ± 100 mL minute −1 m −2 ; p = 0.0008) and CaO 2 (13.2 ± 1.53 to 8.4 ± 2.05 mL dL −1 ; p = 0.0001) from FIO 2 0.21 to 0.10, but not at remaining FIO 2 values. The correlation between StO 2 and D . O 2 I across all FIO 2 values was strong ( r = 0.97; p = 0.0013) and linear. Conclusions and clinical relevance In this model of hypoxemia and hyperoxemia, the strong correlation between StO 2 and D . O 2 I suggests that StO 2 can be used to estimate D . O 2 . |
| Databáze: | OpenAIRE |
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