Hypoglycemic triterpenoid glycosides from Cyclocarya paliurus (Sweet Tea Tree)
| Autor: | Jing Li, Tong-Yao Xuan, Hui-Hui Sun, Jian-Ping Wu, Wen-Xuan Wang, Zhi-Chun Yang, Zhen-Xing Zou, Kang-Ping Xu, Zu-Hui Chen, Wen-Yan Lv, Jialing Xu, Zi-Jun Ye, Hui Zhu, Jie Tan |
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| Rok vydání: | 2019 |
| Předmět: |
01 natural sciences
Biochemistry Juglandaceae chemistry.chemical_compound Mice Structure-Activity Relationship Triterpenoid 3T3-L1 Cells Drug Discovery Adipocytes Bioassay Animals Hypoglycemic Agents Glycosides Molecular Biology chemistry.chemical_classification biology Traditional medicine Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry Dammarane Glycoside Carbon-13 NMR biology.organism_classification Triterpenes 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry Paliurus Glucose Two-dimensional nuclear magnetic resonance spectroscopy Cyclocarya |
| Zdroj: | Bioorganic chemistry. 95 |
| ISSN: | 1090-2120 |
| Popis: | Four new rarely occurred seco-dammarane triterpenoid glycosides (1-4) and four new dammarane triterpenoid glycosides (5-8), along with four known triterpenoids (9-12), were isolated from the 70% ethanol extract of the leaves of Cyclocarya paliurus (family Juglandaceae). Their structures were elucidated by extensive spectroscopic methods, including 1D/2D NMR and HRESIMS data, together with chemical analysis and DFT GIAO 13C NMR calculation. In bioassay, compounds 5-8 significantly increased glucose consumption in 3T3-L1 adipocytes, which could be the bioactive constituents for the anti-diabetes effect of the traditional usage of C. paliurus. |
| Databáze: | OpenAIRE |
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