Acquired Coagulation Factor V Inhibitor That Was Successfully Treated with Oral Corticosteroid Therapy
| Autor: | Hiromichi Bamba, Minami Nakagawa, Masaki Iwasa, Kousuke Hiroe, Katsuyuki Kito, Rie Osaki, Akira Andoh, Masahiro Kawahara, Kazuki Kakuda, Osamu Inatomi, Yoshihiro Yokota, Shigeki Sakai |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
pancreatic cancer Factor V inhibitor Oral prednisolone Gastroenterology corticosteroids Adrenal Cortex Hormones Pancreatic cancer Internal medicine Internal Medicine medicine Humans Blood Coagulation factor V inhibitor Aged Blood Coagulation Factor Inhibitors biology business.industry Factor V General Medicine Coagulation factor V medicine.disease Coagulation Corticosteroid therapy biology.protein Female Blood Coagulation Tests Antibody Coagulation factor V inhibitor business |
| Zdroj: | Internal Medicine. 60:2663-2666 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.7453-21 |
| Popis: | Acquired coagulation factor V (FV) inhibitors are rare disorders in which antibodies against FV develop under various conditions. We herein report the case of a 71-year-old woman with FV inhibitor during radiochemotherapy for pancreatic cancer. Multiple purpuras suddenly appeared on her bilateral upper limbs with prolonged coagulation data (APTT 97.3 seconds). The FV activity was less than 3% and the FV inhibitor was positive (1.7 B.U./mL). Oral prednisolone induced a rapid normalization of the coagulation data and FV activity and a rapid disappearance of FV inhibitor within 7 days. Early diagnosis and treatment may therefore be important in cases of FV inhibitor. |
| Databáze: | OpenAIRE |
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