| Autor: |
Kimberly Stegmaier, Thomas Oellerich, John C. Byrd, Scott A. Armstrong, Federica Piccioni, James S. Blachly, Alison R. Walker, Arati V. Rao, Sebastian Mohr, Björn Häupl, Amy Goodale, Amanda Robichaud, Yana Pikman, S. Haihua Chu, Linda Ross, Elizabeth S. Frank, Gabriela Alexe, Jana M. Ellegast, Anjali Cremer |
| Rok vydání: |
2023 |
| DOI: |
10.1158/2159-8290.22535737 |
| Popis: |
Fig. S1: Characterization of effects of Entospletinib in AML in vitro and in vivo, Fig. S2: Genome-scale lentiviral ORFeome library screen identifies drivers of entospletinib resistance in AML.; Fig. S3: Viability analysis with increasing concentrations of PRT062067; Fig. S4: Characterization of a MV4-11 cell line with acquired resistance to entospletinib; Fig. S5: PTPN11 mutants confer resistance to entospletinib in AML; Fig S6: Combination of a MEK-Inhibitor and a SYK-Inhibitor is synergistic in in vitro AML models; Fig. S7: Combination of a MEK inhibitor and a SYK inhibitor shows no toxicity in healthy mice |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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