Determination of biological activity of adinazolam and its metabolites
| Autor: | Daniels Eg, Collins Rj, Vimala H. Sethy |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.drug_class Pharmaceutical Science Flunitrazepam Pharmacology In Vitro Techniques Bicuculline Adinazolam chemistry.chemical_compound Benzodiazepines medicine Animals Active metabolite Binding affinities Benzodiazepine Muscimol Cell Membrane Brain Biological activity Rats Inbred Strains Metabolism Receptors GABA-A Rats chemistry Anti-Anxiety Agents psychological phenomena and processes medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 36(8) |
| ISSN: | 0022-3573 |
| Popis: | Adinazolam and its metabolites inhibit [3H]flunitrazepam binding in-vitro. The binding affinities of these compounds is significantly enhanced in the presence of 10-5 M muscimol, indicating that both adinazolam and its metabolites are benzodiazepine agonists. In-vivo metabolism of adinazolam results in the formation of active metabolites. |
| Databáze: | OpenAIRE |
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