Dual control of the vestibulosympathetic reflex following hypotension in rats
| Autor: | Byung Rim Park, Sang Eon Park, Yuan-Zhe Jin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Epinephrine Intermediolateral cell column Physiology AMPA receptor Vestibulosympathetic reflex 03 medical and health sciences Orthostatic vital signs chemistry.chemical_compound 0302 clinical medicine pERK Internal medicine medicine Glutamate receptor antagonist Pharmacology Orthostatic hypotension business.industry Rostral ventrolateral medulla 030104 developmental biology medicine.anatomical_structure Endocrinology Blood pressure chemistry Anesthesia NMDA receptor Original Article Glutamate Adrenal medulla business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology |
| ISSN: | 1226-4512 |
| Popis: | Orthostatic hypotension (OH) is associated with symptoms including headache, dizziness, and syncope. The incidence of OH increases with age. Attenuation of the vestibulosympathetic reflex (VSR) is also associated with an increased incidence of OH. In order to understand the pathophysiology of OH, we investigated the physiological characteristics of the VSR in the disorder. We applied sodium nitroprusside (SNP) to conscious rats with sinoaortic denervation in order to induce hypotension. Expression of pERK in the intermediolateral cell column (IMC) of the T4~7 thoracic spinal regions, blood epinephrine levels, and blood pressure were evaluated following the administration of glutamate and/or SNP. SNP-induced hypotension led to increased pERK expression in the medial vestibular nucleus (MVN), rostral ventrolateral medullary nucleus (RVLM) and the IMC, as well as increased blood epinephrine levels. We co-administered either a glutamate receptor agonist or a glutamate receptor antagonist to the MVN or the RVLM. The administration of the glutamate receptor agonists, AMPA or NMDA, to the MVN or RVLM led to elevated blood pressure, increased pERK expression in the IMC, and increased blood epinephrine levels. Administration of the glutamate receptor antagonists, CNQX or MK801, to the MVN or RVLM attenuated the increased pERK expression and blood epinephrine levels caused by SNP-induced hypotension. These results suggest that two components of the pathway which maintains blood pressure are involved in the VSR induced by SNP. These are the neurogenic control of blood pressure via the RVLM and the humoral control of blood pressure via epinephrine release from the adrenal medulla. |
| Databáze: | OpenAIRE |
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