Rimantadine pharmacokinetics after single and multiple doses
| Autor: | D A Farolino, N Keigher, R J Wills, Nadia Choma |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Adolescent Rimantadine Adult male Adamantane Pharmacology Multiple dose Multiple dosing Drug Administration Schedule Random Allocation Pharmacokinetics Oral administration medicine Humans Pharmacology (medical) Random allocation business.industry Kinetics Regimen Infectious Diseases Anesthesia business Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 31:826-828 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.31.5.826 |
| Popis: | Twenty-four healthy adult male volunteers were randomly assigned to one of two rimantadine regimens. The 12 volunteers assigned to regimen 1 orally received a single 100-mg rimantadine tablet followed 5 days later by 100 mg of rimantadine twice a day for 10 days. Volunteers assigned to regimen 2 ingested a single 100-mg rimantadine tablet followed 5 days later by 100 mg once a day for 10 days. The results of the study suggest that the pharmacokinetics of rimantadine are linear and accumulation of the drug during repetitive multiple doses is predictable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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