Continuous Optical Monitoring of Spinal Cord Oxygenation and Hemodynamics during the First Seven Days Post-Injury in a Porcine Model of Acute Spinal Cord Injury
| Autor: | Seth Tigchelaar, Neda Manouchehri, Shera Fisk, Andrew J. Macnab, Megan Webster, Lorna Tu, Brian K. Kwon, Amanda Cheung, Sara S. Dalkilic, Babak Shadgan, Kyoung-Tae Kim, Kitty So, Eric C Sayre, Femke Streijger |
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| Rok vydání: | 2020 |
| Předmět: |
030506 rehabilitation
Swine Hemodynamics Prom Post injury 03 medical and health sciences 0302 clinical medicine medicine Animals Spinal cord injury Spinal Cord Injuries Spectroscopy Near-Infrared business.industry Oxygenation Spinal cord medicine.disease Neurophysiological Monitoring female genital diseases and pregnancy complications Disease Models Animal Blood pressure medicine.anatomical_structure Spinal Cord Anesthesia Acute spinal cord injury Swine Miniature Female Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma. 37:2292-2301 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2020.7086 |
| Popis: | One of the only currently available treatment options to potentially improve neurological recovery after acute spinal cord injury (SCI) is augmentation of mean arterial blood pressure (MAP) to promote blood flow and oxygen delivery to the injured cord. However, to optimize such hemodynamic management, clinicians require a method to monitor the physiological effects of these MAP alterations within the injured cord. Therefore, we investigated the feasibility and effectiveness of using a novel optical sensor, based on near-infrared spectroscopy (NIRS), to monitor real-time spinal cord oxygenation and hemodynamics during the first 7 days post-injury in a porcine model of acute SCI. Six Yucatan miniature pigs underwent a T10 vertebral level contusion-compression injury. Spinal cord oxygenation and hemodynamics were continuously monitored by a minimally invasive custom-made NIRS sensor, and by invasive intraparenchymal (IP) probes to validate the NIRS measures. Episodes of MAP alteration and hypoxia were performed acutely after injury, and at 2 and 7 days post-injury to simulate the types of hemodynamic changes SCI patients experience after injury. The NIRS sensor demonstrated the ability to provide oxygenation and hemodynamic measurements over the 7-day post-SCI period. NIRS measures showed statistically significant correlations with each of the invasive IP measures and MAP changes during episodes of MAP alteration and hypoxia throughout the first week post-injury ( |
| Databáze: | OpenAIRE |
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