Recent insights into body weight control: From physiology to pathology
| Autor: | A Madej, Bogusław Okopień, Zbigniew S. Herman, Robert Krysiak, Belowski D |
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| Rok vydání: | 2001 |
| Předmět: |
Leptin
medicine.medical_specialty Corticotropin-Releasing Hormone media_common.quotation_subject Appetite Biology Body weight Biochemistry Structural Biology Internal medicine Orexigenic Drug Discovery medicine Animals Humans Drug Interactions Neuropeptide Y Melanocyte-Stimulating Hormones Obesity Molecular Biology Melanocortins media_common Pharmacology Body Weight Organic Chemistry General Medicine Neuropeptide Y receptor medicine.disease Endocrinology Molecular Medicine hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Journal of Peptide Science. 7:571-578 |
| ISSN: | 1099-1387 1075-2617 |
| Popis: | Over the past several years, new modulators of feeding and body weight have been discovered, and our knowledge of the mechanisms and neurohumoral interactions between anorexigenic and orexigenic compounds has increased dramatically. This review aims to summarize the present knowledge of the role of leptin and several hypothalamic neuropeptides, such as neuropeptide Y (NPY), corticotropin-releasing hormone (CRH) and melanocortins, in the regulation of appetite and body weight. It also presents the progress made in the design of interactions between leptin and hypothalamic peptides in the regulation of feeding. The role of these compounds in the pathogenesis of obesity in animals and humans, and their potential usefulness in the treatment of this disorder, are discussed. Copyright © 2000 European Peptide Society and John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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