Plasma levels of oxidative stress in children with steroid-sensitive nephrotic syndrome and their predictive value for relapse frequency

Autor: Huizhen Tan, Ying Mo, Jinhua Li, Aiwen Fan, Mengjie Jiang, Xiaoyun Jiang
Rok vydání: 2015
Předmět:
0301 basic medicine
Nephrology
Male
medicine.medical_specialty
Pediatrics
Nephrotic Syndrome
Time Factors
Adolescent
Steroid-sensitive nephrotic syndrome
030204 cardiovascular system & hematology
medicine.disease_cause
Gastroenterology
Superoxide dismutase
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Predictive Value of Tests
Recurrence
Risk Factors
Internal medicine
Malondialdehyde
Medicine
Humans
Prospective Studies
Child
biology
business.industry
Superoxide Dismutase
Infant
Plasma levels
medicine.disease
Oxidative Stress
030104 developmental biology
Treatment Outcome
Advanced oxidation protein products
chemistry
Advanced Oxidation Protein Products
Case-Control Studies
Child
Preschool
Pediatrics
Perinatology and Child Health
biology.protein
Female
Steroids
business
Nephrotic syndrome
Oxidative stress
Biomarkers
Zdroj: Pediatric nephrology (Berlin, Germany). 31(1)
ISSN: 1432-198X
Popis: Oxidative stress has been reported to play an important role in children with primary nephrotic syndrome (PNS). However, the results of previous studies are controversial. Forty children with steroid-sensitive nephrotic syndrome (SSNS) and 20 age- and sex-matched healthy controls were enrolled. Patients were followed-up for 12-18 months and divided into three subgroups: frequent relapse (n = 10), non-frequent relapse (n = 12), and non-relapse (n = 18). The plasma levels of advanced oxidation protein products (AOPP), malondialdehyde (MDA), and superoxide dismutase (SOD) were tested in controls and patient group at first presentation and after 4 weeks of steroid treatment. Patients had higher AOPP and MDA levels but lower SOD compared with controls. AOPP levels were significantly higher in the frequent relapse subgroup compared with the non-frequent relapse and non-relapse subgroups, respectively. No significant differences were found in the plasma levels of MDA and SOD among the three subgroups. AOPP >87.55 μmol/l before steroid treatment and AOPP >78.5 μmol/l after 4-week steroid treatment were positively correlated with the relapse frequency in patients with SSNS. Children with SSNS have oxidative stress. The plasma levels of AOPP before and after 4-week steroid treatment may predict whether patients with SSNS will relapse frequently.
Databáze: OpenAIRE
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