Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels
Autor: | Andreas Müller, Qiaoli Ma, Steven T. Proulx, Benjamin V. Ineichen, Yann Decker |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Sacrum Immunology Carbazoles Contrast Media Mice Transgenic 610 Medicine & health Subarachnoid Space Lymphatic System 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid medicine Immunology and Allergy Animals Spinal cord injury Research Articles Cerebrospinal Fluid Lymphatic Vessels medicine.diagnostic_test business.industry Multiple sclerosis Cranial nerves Lumbosacral Region Brief Definitive Report Magnetic resonance imaging Anatomy medicine.disease musculoskeletal system Spinal column Magnetic Resonance Imaging Buprenorphine Analgesics Opioid Mice Inbred C57BL 030104 developmental biology Lymphatic system medicine.anatomical_structure 570 Life sciences biology Subarachnoid space business 030217 neurology & neurosurgery |
Zdroj: | Ma, Qiaoli; Decker, Yann; Müller, Andreas; Ineichen, Benjamin V; Proulx, Steven T. (2019). Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels. Journal of experimental medicine, 216(11), pp. 2492-2502. Rockefeller University Press 10.1084/jem.20190351 Journal of Experimental Medicine, 216 (11) The Journal of Experimental Medicine |
ISSN: | 0022-1007 1540-0069 1540-9538 |
Popis: | The pathways of circulation and clearance of cerebrospinal fluid (CSF) in the spine have yet to be elucidated. We have recently shown with dynamic in vivo imaging that routes of outflow of CSF in mice occur along cranial nerves to extracranial lymphatic vessels. Here, we use near-infrared and magnetic resonance imaging to demonstrate the flow of CSF tracers within the spinal column and reveal the major spinal pathways for outflow to lymphatic vessels in mice. We found that after intraventricular injection, a spread of CSF tracers occurs within both the central canal and the spinal subarachnoid space toward the caudal end of the spine. Outflow of CSF tracers from the spinal subarachnoid space occurred predominantly from intravertebral regions of the sacral spine to lymphatic vessels, leading to sacral and iliac LNs. Clearance of CSF from the spine to lymphatic vessels may have significance for many conditions, including multiple sclerosis and spinal cord injury. Journal of Experimental Medicine, 216 (11) ISSN:0022-1007 ISSN:1540-0069 ISSN:1540-9538 |
Databáze: | OpenAIRE |
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