Anti-inflammatory prenylbenzaldehyde derivatives isolated from Eurotium cristatum
| Autor: | Yanlian Deng, Senhua Chen, Lan Liu, Yan Sujun, Panpan Zhang, Jing Li, Bin Chen, Chunxiu Jia |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Stereochemistry medicine.drug_class Drug Evaluation Preclinical Antineoplastic Agents Plant Science Fungus Horticulture Crystallography X-Ray 01 natural sciences Biochemistry Anti-inflammatory Inhibitory Concentration 50 Mice chemistry.chemical_compound Cell Line Tumor Eurotium medicine Ic50 values Animals Humans Molecular Biology Natural product Molecular Structure biology 010405 organic chemistry Chemistry Anti-Inflammatory Agents Non-Steroidal Aspergillaceae General Medicine biology.organism_classification 0104 chemical sciences Quinone RAW 264.7 Cells Benzaldehydes 010606 plant biology & botany |
| Zdroj: | Phytochemistry. 158:120-125 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/j.phytochem.2018.11.017 |
| Popis: | Two undescribed prenylbenzaldehyde derivatives, cristaldehydes A and B, and an undescribed quinone derivative, cristaquinone A, along with seven known compounds were isolated from the fungus Eurotium cristatum. The structures of undescribed compounds were determined by spectroscopic analysis including NMR, HR-ESIMS, and single-crystal X-ray diffraction. This is the first report of identification of a dibenzannulated 6,6-spiroketal derivative, cristaldehyde B, in a natural product. Cytotoxic and anti-inflammatory activities of all compounds were evaluated. Cristaldehyde A and cristaquinone A along with five known compounds showed significant anti-inflammatory activities with IC50 values in the range from 0.37 to 14.50 μM. |
| Databáze: | OpenAIRE |
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