Tripterygium and its extracts for diabetic nephropathy: Efficacy and pharmacological mechanisms
| Autor: | Zheng-dong Feng, Wei-Jun Huang, Qi Jia, Yong-Hua Xiao, Shi-Dong Wang, Weijing Liu, Xueting Han, Jin-Xi Zhao, Rui-xi Sun, Yao Xiao, Hui Juan Zheng, Zebing Zhu, He Nan, Chenhui Xia, Han-xue Jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Efficacy Tripterygium p38 mitogen-activated protein kinases Renal function Diabetic nephropathy RM1-950 Pharmacology Pharmacological mechanism Diabetes Mellitus Experimental 03 medical and health sciences 0302 clinical medicine Medicine Animals Humans Diabetic Nephropathies Adverse effect Protein kinase B Clinical Trials as Topic biology Mechanism (biology) business.industry Plant Extracts Wnt signaling pathway General Medicine biology.organism_classification medicine.disease 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis Therapeutics. Pharmacology Inflammation Mediators business |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 121, Iss, Pp 109599-(2020) |
| ISSN: | 0753-3322 |
| Popis: | Diabetic nephropathy (DN) is a common but intractable diabetic microvascular complication. Tripterygium, a Chinses herb, has been proven to be effective for DN treatment. In this review, the efficacy and pharmacological mechanism of tripterygium and its extracts on DN is elucidated. Tripterygium and its extracts could effectively reduce urine protein and protect renal function. Its pharmacological mechanism involves anti-inflammation, anti-oxidation, anti-glomerulosclerosis and anti-fibrosis, which is achieved by balancing the Th1/Th2 cells, regulating macrophage infiltration, and regulating the following pathways: p38 MAPK, NF-κB, TGF-β, Wnt/β-catenin, Akt and Notch1. Although tripterygium and its extracts may result in some adverse effects, including liver-function damage, gastrointestinal reaction, menstrual disorders, and reproductive problems, they are considered good alternative medicines for DN if used with caution and in the proper manner. |
| Databáze: | OpenAIRE |
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