Effects of a positively charged biomaterial for dermal and subcutaneous augmentation
| Autor: | Barry L. Eppley, Don-John Summerlin, A M Sadove, Christopher D. Prevel |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Pathology Injections Subcutaneous Dermatologic Surgical Procedures Connective tissue Rats Sprague-Dawley chemistry.chemical_compound Dermis Cations Materials Testing Animals Medicine Surgery Plastic Fibroblast Skin Wound Healing business.industry Macrophages DEAE-Dextran Biomaterial Fibroblasts Rats Surgery medicine.anatomical_structure Dextran chemistry Connective Tissue Chronic inflammatory response Female Collagen business Wound healing Subcutaneous tissue |
| Zdroj: | Aesthetic Plastic Surgery. 18:413-416 |
| ISSN: | 1432-5241 0364-216X |
| DOI: | 10.1007/bf00451350 |
| Popis: | Based on previous experimental connective tissue work, the use of a positively charged dextran-based biomaterial in subcutaneous tissue sites was evaluated. After hydration with saline, the biomaterial was injected beneath the abdominal skin in rats. A robust macrophage response was initially seen at 30 days without acute inflammation. By one year postoperatively, extensive intermaterial fibroblast and collagen ingrowth had occurred. No evidence of a foreign-body or chronic inflammatory response was seen. These preliminary findings suggest good tissue compatibility of this biomaterial and suggests that when combined with a biocompatible liquid medium, the potential for development of a bioactive dermal and subcutaneous injectable substance exists. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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