Optimization Studies on the Hydro-acylation of 1-Alkenes to α-Methylketones using a Homogeneous Palladium/Josiphos Catalyst
| Autor: | Bart Hessen, Hero J. Heeres, Hans Heeres, Adri J. Minnaard |
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| Přispěvatelé: | Engineering and Technology Institute Groningen |
| Rok vydání: | 2012 |
| Předmět: |
DIMERIZATION
Chemistry Ligand Organic Chemistry ASSIGNMENT chemistry.chemical_element Partial pressure Catalysis Acylation POLYMERIZATION REDUCTION chemistry.chemical_compound Homogeneous Organic chemistry COMPLEXES ETHENE Physical and Theoretical Chemistry CARBON-MONOXIDE ALTERNATING COPOLYMERIZATION Selectivity Dichloromethane Palladium |
| Zdroj: | Organic Process Research & Development, 16(3), 400-408. AMER CHEMICAL SOC INC |
| ISSN: | 1520-586X 1083-6160 |
| Popis: | The effect of process conditions (temperature, partial pressures of CO and H2) on the product selectivity and ee of the palladium-catalysed asymmetric hydro-acylation of 1-pentene in dichloromethane with the chiral Josiphos ligand (SL-J008-1, L1) was investigated. The highest ee value (73%) for the desired product 4-methyl-5-decanone (1) was obtained at the lowest temperature in the range (30 °C). The selectivity for 1 was between 12 and 20 mol % at 30 °C, though considerably higher at 90 °C (59 mol %). Statistical modeling was applied to quantify the influence of the process conditions on the product selectivity and ee. |
| Databáze: | OpenAIRE |
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