Effect of a Selective Inhibitor of Secretory Phospholipase A2, S-5920/LY315920Na, on Experimental Acute Pancreatitis in Rats
| Autor: | Tetsuo Ajiki, Katsutoshi Yamada, Masahiko Ueno, Kenji Kuwabara, Toshiyuki Maruyama, Shingo Furue, Kazushige Tanaka, Takashi Ono, Yozo Hori, Hirohiko Onoyama, Masahiro Yamamoto, Yasuhiko Tomita |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Indoles Acetates In Vitro Techniques Phospholipases A Phospholipase A2 Internal medicine Edema Ascites medicine Animals Group IB Phospholipases A2 Fat necrosis Amylase Rats Wistar Lipase Pharmacology Dose-Response Relationship Drug biology business.industry lcsh:RM1-950 medicine.disease Keto Acids Rats Phospholipases A2 Endocrinology lcsh:Therapeutics. Pharmacology Pancreatitis Acute Disease biology.protein Molecular Medicine Acute pancreatitis medicine.symptom business |
| Zdroj: | Journal of Pharmacological Sciences, Vol 96, Iss 2, Pp 144-154 (2004) |
| ISSN: | 1347-8613 |
| Popis: | We investigated the efficacy of a potent inhibitor of secretory phospholipase A2 (sPLA2), S-5920/LY315920Na, in an experimental model of acute pancreatitis in rats. Combined intraductal injection of sodium taurocholate (5 mg/rat) and porcine pancreatic sPLA2-IB (300 μg/rat) caused severe hemorrhagic necrotizing pancreatitis resulting in high mortality, along with rapid increases of catalytic PLA2 and lipase activities in plasma and ascites and with gradual increases of plasma amylase and aspartate aminotransferase levels over 9 h after the pancreatitis. Prophylactic intravenous treatment with S-5920/LY315920Na significantly reduced mortality at 7 days, and strongly abrogated PLA2 activities in both plasma and ascites along with significant reduction of lipase activity, amylase, aspartate aminotransferase, and hemorrhage at 6 h. It also significantly reduced histological damage such as edema and parenchymal and fat necroses of the pancreatic tissue. This sPLA2 inhibitor could become an effective agent for the treatment of severe acute pancreatitis. Keywords:: phospholipase A2, pancreatitis, parenchymal necrosis, S-5920/LY315920Na |
| Databáze: | OpenAIRE |
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