Reflux Disease and Laryngeal Neoplasia in Nonsmokers and Nondrinkers
| Autor: | Ryan Winters, Andrew L. Iarocci, Mariella Gastañaduy, Edward D. McCoul, Sean M. Parsel, Jeffrey P Marino |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Alcohol Drinking Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Odds Ratio medicine Carcinoma Humans Risk factor 030223 otorhinolaryngology Laryngeal Neoplasms Aged Aged 80 and over Univariate analysis business.industry Carcinoma in situ Smoking Head and neck cancer Cancer Odds ratio Middle Aged medicine.disease humanities digestive system diseases Otorhinolaryngology Case-Control Studies 030220 oncology & carcinogenesis Gastroesophageal Reflux GERD Female Surgery business Carcinoma in Situ |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 163:560-562 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1177/0194599820917669 |
| Popis: | Gastroesophageal reflux disease (GERD) has been hypothesized as a risk factor for development of laryngeal cancer. A case-control study was performed to assess the association of laryngeal neoplasia with GERD. Cases consisted of patients with a history of laryngeal cancer or carcinoma in situ. Controls were patients without neoplasia who matched cases 2:1 on age, sex, race, and smoking history. Univariate and multivariate analyses were performed to assess risk of laryngeal neoplasia and GERD. In total, 2094 patients were included. Cases had higher rates of GERD. Univariate analysis demonstrated a positive association between GERD and laryngeal neoplasia (odds ratio, 1.33; 95% CI, 1.07-1.64). Multivariate analysis controlling for alcohol use history also demonstrated a positive association between GERD and laryngeal neoplasia (adjusted odds ratio, 1.29; 95% CI, 1.04-1.59). These results suggest increased odds of laryngeal carcinoma and carcinoma in situ in patients with GERD when controlling for smoking and drinking history. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text