Occurrence of binding sites for [ 125 I] ANP in the myocardium but not in Purkinje fibers of the bovine heart
| Autor: | C Barroso, M. Hansson, S. Gulbenkian, Sture Forsgren |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Histology medicine.drug_class Purkinje fibers In Vitro Techniques Pathology and Forensic Medicine Iodine Radioisotopes Purkinje Fibers Atrial natriuretic peptide Heart Conduction System Internal medicine medicine Natriuretic peptide Animals cardiovascular diseases Receptor Autocrine signalling Binding Sites Chemistry Myocardium Cell Biology NPR1 NPR2 Endocrinology medicine.anatomical_structure cardiovascular system Autoradiography Cattle Electrical conduction system of the heart Receptors Atrial Natriuretic Factor Atrial Natriuretic Factor |
| Zdroj: | Cell and Tissue Research. 290:669-673 |
| ISSN: | 1432-0878 0302-766X |
| Popis: | Atrial natriuretic peptide has frequently been detected in the cardiac conduction system and has been shown to regulate some intracellular effects in Purkinje fibers. To determine if atrial natriuretic peptide works as an autocrine and/or paracrine hormone on cardiac Purkinje fibers, we examined the different parts of the conduction system in the bovine heart by use of in vitro receptor autoradiography. In no parts of the bovine conduction system were specific binding sites for [125I] atrial natriuretic peptide observed, whereas the ventricular myocardium exhibited a large number of [125I] atrial natriuretic peptide binding sites. This is the first morphologic study showing the presence of [125I] atrial natriuretic peptide binding sites in the ventricular myocardium and their absence in the conduction system. The present observations together with results obtained in studies using other methods strongly suggest that natriuretic peptide receptors are localized on ventricular myocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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