Pangenomic changes induced by DHEA in the skin of postmenopausal women
| Autor: | Ezequiel Calvo, Jean Morissette, Jacques Leclaire, B. Bernard, Claude Labrie, Céline Martel, Véronique Chaussade, Fernand Labrie, Françoise Bernerd, Van Luu-The, Claire Deloche |
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| Rok vydání: | 2008 |
| Předmět: |
Keratinocytes
medicine.medical_specialty Microarray Endocrinology Diabetes and Metabolism Cellular differentiation Administration Topical Clinical Biochemistry Dehydroepiandrosterone Stimulation Human skin Biology Biochemistry Endocrinology Dermis Internal medicine medicine Humans skin and connective tissue diseases Molecular Biology Aged Cell Proliferation Skin Reverse Transcriptase Polymerase Chain Reaction Gene Expression Profiling Cell Differentiation Cell Biology Middle Aged Gene expression profiling Postmenopause medicine.anatomical_structure Molecular Medicine Female Keratinocyte |
| Zdroj: | The Journal of steroid biochemistry and molecular biology. 112(4-5) |
| ISSN: | 0960-0760 |
| Popis: | The objective of this study was to explore, for the first time, the changes in the pangenomic profile induced in human skin in women treated with dehydroepiandrosterone (DHEA) applied locally. Sixty postmenopausal women participated in this phase II prospective, randomized, double-blind and placebo-controlled study. Women were randomized to the twice daily local application of 0% (placebo), 0.3%, 1% or 2% DHEA cream. Changes in the pangenomic expression profile were studied using Affymetrix Genechips. Significant changes (p |
| Databáze: | OpenAIRE |
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