STAT4 gene polymorphism in patients after renal allograft transplantation
| Autor: | Andrzej Pawlik, Krzysztof Safranow, Sylwia Słuczanowska-Głabowska, Violetta Dziedziejko, Leszek Domański, Ewa Dąbrowska-Żamojcin |
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| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine kidney medicine.medical_specialty Immunology Biology polymorphism STAT4 03 medical and health sciences 0302 clinical medicine Immune system immune system diseases STAT4 gene Polymorphism (computer science) Internal medicine medicine Immunology and Allergy skin and connective tissue diseases Kidney hemic and immune systems Transplantation surgical procedures operative 030104 developmental biology medicine.anatomical_structure Endocrinology graft Renal allograft STAT protein Clinical Immunology 030215 immunology |
| Zdroj: | Central-European Journal of Immunology |
| ISSN: | 1426-3912 |
| DOI: | 10.5114/ceji.2016.63124 |
| Popis: | Introduction STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. The most commonly studied polymorphism in the STAT4 gene is rs7574865. In our study, we examined whether this polymorphism is associated with the early and late functions of renal allografts. Material and methods A total of 270 recipients of first renal transplants were included in the study. Single nucleotide polymorphisms (SNPs) within the STAT4 gene were genotyped using TaqMan genotyping assays. Results There were no statistically significant associations between the STAT4 gene rs7574865 polymorphism and delayed graft function, acute rejection, chronic allograft dysfunction, post-transplant diabetes mellitus, or creatinine serum concentrations after transplantation. Conclusions Our results suggest a lack of association between the STAT4 rs7574865 SNP and kidney allograft function in the Polish population. |
| Databáze: | OpenAIRE |
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