Corticotropin-Releasing Factor (CRF) circuit modulation of cognition and motivation
| Autor: | Rita J. Valentino, Stan B. Floresco, Debra A. Bangasser, Craig W. Berridge, Sofiya Hupalo, Courtney A. Bryce |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Corticotropin-Releasing Hormone Cognitive Neuroscience Decision Making Article 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Cognition Monoaminergic Medicine Animals Humans 0501 psychology and cognitive sciences Attention Cognitive Dysfunction 050102 behavioral science & comparative psychology Prefrontal cortex Motivation business.industry Working memory 05 social sciences Cognitive flexibility Brain Mental illness medicine.disease 3. Good health Neuropsychology and Physiological Psychology Memory Short-Term Cholinergic Anxiety Female medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurosci Biobehav Rev |
| ISSN: | 1873-7528 |
| Popis: | The neuropeptide, corticotropin-releasing factor (CRF), is a key modulator of physiological, endocrine, and behavioral responses during stress. Dysfunction of the CRF system has been observed in stress-related affective disorders including post-traumatic stress disorder, depression, and anxiety. Beyond affective symptoms, these disorders are also characterized by impaired cognition, for which current pharmacological treatments are lacking. Thus, there is a need for pro-cognitive treatments to improve quality of life for individuals suffering from mental illness. In this review, we highlight research demonstrating that CRF elicits potent modulatory effects on higher-order cognition via actions within the prefrontal cortex and subcortical monoaminergic and cholinergic systems. Additionally, we identify questions for future preclinical research on this topic, such as the need to investigate sex differences in the cognitive and microcircuit actions of CRF, and whether CRF may represent a pharmacological target to treat cognitive dysfunction. Addressing these questions will provide new insight into pathophysiology underlying cognitive dysfunction and may lead to improved treatments for neuropsychiatric disorders. |
| Databáze: | OpenAIRE |
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