Solution-combustion synthesis of doped TiO 2 compounds and its potential antileishmanial activity mediated by photodynamic therapy
| Autor: | Claudia García, Leandro da Costa Clementino, Angela Maria Arenas Velásquez, Marcia A. S. Graminha, L.M. de Freitas, Vinícius D.N. Bezzon, A.A. Lopera, Carla Raquel Fontana, Alba Montoya, Sara M. Robledo |
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| Přispěvatelé: | Grupo de Cerámicos y Vítreos, Universidade Estadual Paulista (Unesp), Facultad de Medicina, Universidade de São Paulo (USP) |
| Rok vydání: | 2018 |
| Předmět: |
Leishmanicidal activity
Absorption spectroscopy medicine.medical_treatment Biophysics chemistry.chemical_element Photodynamic therapy 02 engineering and technology 010402 general chemistry Photochemistry 01 natural sciences Oxygen chemistry.chemical_compound Pt-doped TiO2 medicine Radiology Nuclear Medicine and imaging Irradiation Zn-doped TiO2 Radiation Radiological and Ultrasound Technology Doping 021001 nanoscience & nanotechnology Nanostructures 0104 chemical sciences chemistry Titanium dioxide Photocatalysis 0210 nano-technology Visible spectrum |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1011-1344 |
| DOI: | 10.1016/j.jphotobiol.2018.04.017 |
| Popis: | Made available in DSpace on 2018-12-11T16:53:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Photodynamic therapy has emerged as an alternative treatment for cutaneous leishmaniasis, and compounds with photocatalytic behavior are promising candidates to develop new therapeutic strategies for the treatment of this parasitic disease. Titanium dioxide TiO2 is a semiconductor ceramic material that shows excellent photocatalytic and antimicrobial activity under Ultraviolet irradiation. Due to the harmful effects of UV radiation, many efforts have been made in order to enhance both photocatalytic and antimicrobial properties of TiO2 in the visible region of the spectrum by doping or through modifications in the route of synthesis. Herein, Fe-, Zn-, or Pt- doped TiO2 nanostructures were synthesized by solution-combustion route. The obtained compounds presented aggregates of 100 nm, formed by particles smaller than 20 nm. Doping compounds shift the absorption spectrum towards the visible region, allowing production of reactive oxygen species in the presence of oxygen and molecular water when the system is irradiated in the visible spectrum. The Pt (EC50 = 18.2 ± 0.8 μg/mL) and Zn (EC50 = 16.4 ± 0.3 μg/mL) –doped TiO2 presented the higher antileishmanial activities under visible irradiation and their application as photosensitizers in photodynamic therapy (PDT) strategies for the treatment of cutaneous leishmaniasis should be considered. Universidad Nacional de Colombia Sede Medellín Grupo de Cerámicos y Vítreos School of Pharmaceutical Sciences São Paulo State University (UNESP) São Paulo State University (UNESP) Institute of Chemistry Universidad de Antioquia PECET-Instituto de Investigaciones Médicas Facultad de Medicina Department of Pharmacy Faculty of Pharmaceuticals Science University of Sao Paulo School of Pharmaceutical Sciences São Paulo State University (UNESP) São Paulo State University (UNESP) Institute of Chemistry FAPESP: # 14/24581-5 FAPESP: #16/19289-9 FAPESP: #2013/08248-1 FAPESP: #2016/05345-4 FAPESP: #2017/03552-5 |
| Databáze: | OpenAIRE |
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