Interleukin 1β(+3954, −511 and −31) polymorphism in chronic periodontitis patients from North India
| Autor: | Anjana Munshi, Satrupa Das, Akka Jyothy, Ritu Prabha Patel, Ramesh Amirisetty, Jitendra Saraf |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Genotype Interleukin-1beta India Biology Cytosine Gene Frequency Odds Ratio Genetic predisposition medicine Humans Genetic Predisposition to Disease General Dentistry Allele frequency Periodontitis Polymorphism Genetic Haplotype Case-control study Genetic Variation General Medicine Odds ratio Middle Aged medicine.disease Chronic periodontitis Haplotypes Case-Control Studies Chronic Periodontitis Immunology Female Polymorphism Restriction Fragment Length Thymine |
| Zdroj: | Acta Odontologica Scandinavica. 73:343-347 |
| ISSN: | 1502-3850 0001-6357 |
| Popis: | Several studies have implicated the role of interleukin-1 in various chronic diseases including periodontitis. The present study was carried out with an aim to evaluate the role of interleukin 1β polymorphisms, namely +3954C/T, -511C/T and -31T/C, in the development of chronic periodontitis.Twenty-nine chronic periodontitis patients and 31 healthy controls of North Indian origin from Chhattisgarh were recruited for the study. The genotypes for the three variants were determined using the PCR-RFLP technique and the strength of association between genotypes and periodontitis was determined by odds ratio with 95% confidence interval (CI) and chi-square analysis.Analysis for the +3954 allelic and genotypic frequencies of the polymorphism revealed a significant difference in the CT genotype between periodontitits patients and controls (p = 0.03). A significant difference was also observed in the allelic frequencies between the two groups (p = 0.02). For the -511 site, TT genotype revealed a significant association with the disease (p = 0.01). A significant association was also found following the co-dominant model (p = 0.007). However, the -31 polymorphism revealed no significant difference between patients and controls.In conclusion, the present study suggests a strong association of the TT genotype of -511 and CT genotype of +3954 variant of interleukin 1β with chronic periodontitis. However, the -31 variant did not show a significant association with the disease. |
| Databáze: | OpenAIRE |
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