Effect of Melatonin on Sleep in the Perioperative Period after Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial
| Autor: | Jacob Rosenberg, Michael Tvilling Madsen, Ida Hageman, Ismail Gögenur, Melissa Voigt Hansen, Lærke Toftegård Andersen, Lars S. Rasmussen, Susanne Bokmand |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine medicine.medical_specialty Visual Analog Scale Placebo-controlled study Breast Neoplasms law.invention Melatonin 03 medical and health sciences 0302 clinical medicine Breast cancer Double-Blind Method Randomized controlled trial law Humans Hypnotics and Sedatives Medicine Perioperative Period skin and connective tissue diseases Aged business.industry Actigraphy Perioperative Middle Aged medicine.disease Scientific Investigations Sleep in non-human animals Surgery Before Bedtime Neurology 030220 oncology & carcinogenesis Anesthesia Female sense organs Neurology (clinical) Sleep business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Clinical Sleep Medicine. 12:225-233 |
| ISSN: | 1550-9397 1550-9389 |
| DOI: | 10.5664/jcsm.5490 |
| Popis: | To investigate whether administration of an oral dose of 6 mg melatonin before bedtime perioperatively in breast cancer surgery could change sleep outcomes measured by actigraphy.This paper reports secondary outcomes from a double-blind, placebo-controlled, randomized clinical trial where patients received 6 mg melatonin (n = 27) or placebo (n = 21) approximately 60 minutes before bedtime 3 nights preoperatively until at least one week postoperatively. Participants were monitored in the entire period with actigraphy, and were instructed to complete visual analogue scale (VAS) for sleep, and the Karolinska Sleepiness Scale (KSS) each morning.Administration of 6 mg oral melatonin approximately 1 hour before bedtime resulted in significantly increased sleep efficiency and reduced wake after sleep onset for the entire 2-week postoperative period. No other significant differences for actigraphy determined sleep outcomes or subjective outcome parameters in the perioperative period were found between the groups. Overall, the patients sleep outcomes were within normal ranges and no participants had pathological sleep disturbances.Melatonin significantly changed sleep efficiency and wake after sleep onset after surgery, but had no effects on other objective sleep outcomes or on subjective sleep quality (VAS and KSS). |
| Databáze: | OpenAIRE |
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