Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates
| Autor: | Šárka Sedláková, Jaroslav Maxa, Oldřich Farsa, Jana Podlipna |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Hydroquinone
Magnesium vasculopathies chemistry.chemical_element Sulfuric acid 5-dihydroxybenzenesulfonic acid salts General Chemistry Zinc Calcium Aminopeptidase Neutralization lcsh:Chemistry effect on CD13 activity chemistry.chemical_compound lcsh:QD1-999 chemistry Biochemistry neovascularization carcinogenesis IC50 |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 80, Iss 5, Pp 605-612 (2015) |
| ISSN: | 1820-7421 0352-5139 |
| Popis: | Calcium, magnesium and zinc 2,5-dihydroxybenzenesulfonates (dobesilates) were synthesized by sulfonation of hydroquinone with sulfuric acid under mild conditions. To form the salts, neutralization with calcium carbonate followed by cation exchange by means of magnesium or zinc sulfates was performed. The dobesilates were characterized by standard spectral methods and by AAS for metal content and then tested for inhibitory activity against aminopeptidase N. Calcium and magnesium 2,5-dihydroxybenzene sulfonates exhibited rather weak inhibitory activity to aminopeptidase N as demonstrated by IC50 values of 978.0 and 832.1 mmol l-1 respectively while zinc 2,5-dihydroxybenzene sulfonate reached the more significant inhibitory activity characterized by IC50 77.4 mmol l-1. The inhibitory activity results suggest that the inhibition of aminopeptidase N could play a role in the anti-angiogenic activity of 2,5-dihydroxybenzenesulfonates. |
| Databáze: | OpenAIRE |
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