Additional file 1: Figure S1. of Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology

Autor: Wiersma, Vera, Hecke, Wim Van, Scheper, Wiep, Osch, Martijn Van, Hermsen, Will, Rozemuller, Annemieke, Hoozemans, Jeroen
Rok vydání: 2016
Předmět:
DOI: 10.6084/m9.figshare.c.3599975_d1.v1
Popis: Semi-quantitative analysis of the Aβ (IC16) and phosphorylated tau (AT8) burden. Representative examples from our cohort showing the amount of Aβ deposits, small phosphorylated tau positive extracellular inclusions and neuritic changes related to prion disease and phosphorylated tau positive tangle-like structures, most often resulting from AD pathology, corresponding to the semi-quantitative scores +, ++ and +++. Aβ images were taken with the 5× objective, tau (positive inclusions/neuritic changes) images with the 10× objective, tau (tangle-like changes) images with the 20× objective. In Table 3 scores for each case are listed. Scores with a/, e.g. +/++, have a burden in-between the classes represented here. Brown staining with DAB, blue staining of the nucleus with haematoxylin. (PDF 1437 kb)
Databáze: OpenAIRE