Long noncoding RNA MYOSLID promotes invasion and metastasis by modulating the partial epithelial-mesenchymal transition program in head and neck squamous cell carcinoma

Autor: Qi-Chao Yang, Lin-Lin Bu, Zhi-Jun Sun, Wen-Feng Zhang, Jia-Li Zhang, Hao Li, Hong-Gang Xiong, Lei Chen, Lei-Lei Yang, Yao Xiao
Rok vydání: 2019
Předmět:
Keratinocytes
Male
0301 basic medicine
Cancer Research
Epithelial-Mesenchymal Transition
Biology
lcsh:RC254-282
Metastasis
03 medical and health sciences
0302 clinical medicine
Cell Movement
Cell Line
Tumor
medicine
Humans
Vimentin
Neoplasm Invasiveness
Epithelial–mesenchymal transition
Partial epithelial to mesenchymal transition
KEGG
PDPN
MYOSLID
Gene knockdown
Membrane Glycoproteins
Tissue microarray
Squamous Cell Carcinoma of Head and Neck
Research
Middle Aged
Cadherins
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Head and neck squamous-cell carcinoma
Long non-coding RNA
Gene Expression Regulation
Neoplastic
stomatognathic diseases
030104 developmental biology
Prognostic biomarkers
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Cancer research
Female
RNA
Long Noncoding
Snail Family Transcription Factors
Cell Adhesion Molecules
Zdroj: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Journal of Experimental & Clinical Cancer Research : CR
ISSN: 1756-9966
Popis: Background Partial epithelial mesenchymal transition (p-EMT) was found to play a potential role in the initial stage of metastasis in human head and neck squamous cell carcinoma (HNSCC). Some long noncoding RNAs (lncRNAs) have been reported to function as promoters or inhibitors of cancer metastasis. This study aimed to identify p-EMT-related lncRNAs in HNSCC. Methods Differentially expressed lncRNAs (DE-lncRNAs) and mRNAs (DEGs) in HNSCC obtained from The Cancer Genome Atlas (TCGA) were screened out by using the “edgeR” package. DE-lncRNAs in the Oral squamous cell carcinoma (OSCC) lncRNA microarray dataset GSE84805 were screened out by using the “limma” package. Slug-related lncRNAs were determined by Pearson correlation analysis (|Pearson correlation coefficient| ≥ 0.4, p
Databáze: OpenAIRE
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