Association of chemokines IP-10/CXCL10 and I-TAC/CXCL11 with insulin resistance and enhance leukocyte endothelial arrest in obesity
| Autor: | Rebeca Ortega, Luisa Hueso, Miguel Civera, Sergio Martínez-Hervás, Marta Peiro, Esther Benito, José T. Real, Maria-Jesus Sanz, Laura Piqueras, Beatriz Moreno |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Male medicine.medical_specialty Chemokine Receptors CXCR3 Type 2 diabetes CXCR3 Biochemistry Insulin resistance Internal medicine Cell Adhesion Leukocytes medicine Humans CXCL10 CXCL11 Obesity Endothelial dysfunction Cells Cultured biology Tumor Necrosis Factor-alpha business.industry Endothelial Cells Cell Biology Middle Aged medicine.disease Chemokine CXCL11 Up-Regulation Chemokine CXCL10 Endocrinology Case-Control Studies biology.protein Female Insulin Resistance Cardiology and Cardiovascular Medicine business Body mass index Signal Transduction |
| Zdroj: | Microvascular Research. 139:104254 |
| ISSN: | 0026-2862 |
| DOI: | 10.1016/j.mvr.2021.104254 |
| Popis: | Background and aims Obesity is a key contributing factor to incidental type 2 diabetes and cardiovascular disease. CXCR3 receptor and its ligands CXCL 10 and 11 are associated with atherosclerosis and cardiovascular disease. The aim of our study was to analyse the role of the CXCR3 ligands on insulin resistance (IR) and endothelial dysfunction in human obesity. Methods and results We have studied 45 obese patients (mean age 44 ± 6 years, body mass index 45 ± 9 kg/m2) who were selected for Roux-Y-gastric bypass surgery and 21 non obese control subjects with similar age and gender distribution. We measured by ELISA the circulating levels of the CXCR3 ligands interferon-γ inducible protein 10 (IP-10/CXCL10) and interferon-γ–inducible T-cell alpha chemoattractant (I-TAC/CXCL11). Using an ex vivo procedure with the flow chamber assay, we have investigated the effect of such chemokines on endothelial leukocytes arrest under dynamic conditions. Peripheral blood levels of CXCL10 and CXCL11 were significantly higher in obese subjects than in controls (p Conclusions The study demonstrates that CXCL10 and CXCL11 are associated with IR and enhance leukocyte endothelial arrest in obese subjects. Blockade of CXCR3 signaling might be a new therapeutic approach for the prevention of obesity-associated cardiovascular co-morbidities. |
| Databáze: | OpenAIRE |
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