Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model
| Autor: | Yafang Li, Zao Wang, Yiqiang Qiao, Huanhuan Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cytoplasm Chemical Radicals Physiology medicine.medical_treatment Ossification Biochemistry Physical Chemistry Rats Sprague-Dawley 0302 clinical medicine Suture (anatomy) Cell Signaling Osteogenesis Medicine and Health Sciences Young adult Musculoskeletal System Multidisciplinary NF-kB Signaling Pathway Muscles NF-kappa B Nucleic acids Chemistry Physiological Parameters Physical Sciences Medicine Bone Remodeling Signal transduction Anatomy Cellular Structures and Organelles Injections Intraperitoneal Research Article Signal Transduction medicine.medical_specialty Palatal Expansion Technique Signal Inhibition Free Radicals Proline Science Intraperitoneal injection Optical density Bone morphogenetic protein Signal pathway 03 medical and health sciences Thiocarbamates Internal medicine DNA-binding proteins medicine Genetics Animals Non-coding RNA Natural antisense transcripts business.industry Palate Body Weight Biology and Life Sciences Proteins 030206 dentistry Cell Biology Soleus Muscles Gene regulation Rats MicroRNAs Endocrinology RNA Gene expression business Physiological Processes 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 7, p e0243108 (2021) |
| ISSN: | 1932-6203 |
| Popis: | In recent years, many studies have found that mechanical tension can activiate NF-kB signal pathway and NF-kB plays an important role in the process of osteogenesis. However, it is still unclear whether this process exists in the anterior palatal suture expansion. In this paper, we mainly studied the effect of intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis index of the anterior palatal suture expansion model in young adult rats. The expansion model is grouped and established: 45 male 8-week-old Sprague-Dawley rats were randomly divided into three groups, an expansion only (EO) group, an expansion plus PDTC (PE) group, and a control group. The results revealed that PDTC inhibited the activity of NF-kB signaling pathway and promote one morphogenetic protein 2 (BMP-2), steocalatin (OCN) expression. Compared with the control group, the optical density (OD) value of BMP in the EO group and PE group rats increased significantly from the first day to the seventh day, and the difference was statistically significant (P |
| Databáze: | OpenAIRE |
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