Synthesis of nine potential synthetic cannabinoid metabolites with a 5F-4OH pentyl side chain from a scalable key intermediate

Autor:	Peter Konradsson, Xiongyu Wu, Jakob Wallgren, Johan Dahlén, Daniel Bopp
Rok vydání:	2020
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry medicine.medical_treatment Metabolite Organic Chemistry Synthetic cannabinoids Key (cryptography) Side chain medicine macromolecular substances Cannabinoid medicine.drug
Zdroj:	Synthetic Communications. 51:776-785
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397911.2020.1854786
Popis:	Synthetic cannabinoid metabolites with a 5F-4OH pentyl side chain are of great interest, and several synthetic methods have been developed for the synthesis of these types of metabolites in the literature, which is either lengthy or inappropriate for upscaling. Herein, a straightforward method has been developed and reported for the synthesis of a key intermediate in four steps with an overall yield of 49% on a multigram scale, and its application in the synthesis of nine potential metabolites of synthetic cannabinoids with a 5F-4OH pentyl side chain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b751bbc4e381ea8f6ee1bcb0e0a935 https://doi.org/10.1080/00397911.2020.1854786 Zobrazit plný text záznamu