Chromosome 10q harbors a susceptibility locus for bipolar disorder in Ashkenazi Jewish families
| Autor: | Julien Mendlewicz, Jurgen Del-Favero, Stephan Claes, Daniel Souery, Dirk Goossens, C. Van Broeckhoven, Maaike Alaerts, T Venken, Ruth Navon, S Sluijs |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Bipolar Disorder Genotype Genetic Linkage Population Cellular and Molecular Neuroscience Genetic linkage Odds Ratio medicine Humans Genetic Predisposition to Disease Bipolar disorder education Molecular Biology Psychiatric genetics Family Health Genetics Linkage (software) education.field_of_study Chromosomes Human Pair 10 Haplotype Chromosome Mapping Chromosome medicine.disease Psychiatry and Mental health Jews Female Lod Score Psychology |
| Zdroj: | Molecular psychiatry Europe PubMed Central |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/sj.mp.4002039 |
| Popis: | We report the results of a 10 cM density genome-wide scan and further fine mapping of three chromosomal candidate regions in 10 Belgian multigenerational families with bipolar (BP) disorder. This two-stage approach revealed significant evidence for linkage on chromosome 10q21.3-10q22.3, showing a maximum multipoint parametric heterogeneity logarithm of odds (HLOD) score of 3.28 and a nonparametric linkage (NPL) score of 4.00. Most of the chromosome 10q evidence was derived from a single, large Ashkenazi Jewish pedigree. Haplotype analysis in this pedigree shows that the patients share a 14-marker haplotype, defining a chromosomal candidate region of 19.2 cM. This region was reported previously as a candidate region for BP disorder in several independent linkage analysis studies and in one large meta-analysis. It was also implicated in a linkage study on schizophrenia (SZ) in Ashkenazi Jewish families. Additionally, we found suggestive evidence for linkage on chromosome 19q13.2-13.4 (HLOD 2.01, NPL 1.09) and chromosome 7q21-q22 (HLOD 1.45, NPL 2.28). Together, these observations suggest that a gene located on chromosome 10q21.3-10q22.3 is underlying the susceptibility both for SZ and for BP disorder in at least the Ashkenazi Jewish population. |
| Databáze: | OpenAIRE |
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