Molecular characterization of genotype XIIIb Newcastle disease virus from central India during 2006–2012: Evidence of its panzootic potential
| Autor: | Nitin V. Kurkure, Megha Kaore, M. T. Shah, Sudhir Morla, Sachin Kumar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
animal structures Genotype Newcastle Disease viruses Newcastle disease virus India Sequence Homology Virulence Microbiology Newcastle disease Poultry Virus Disease Outbreaks 03 medical and health sciences Zoonoses Animals Cluster Analysis Phylogeny Panzootic Molecular Epidemiology biology Phylogenetic tree Outbreak Sequence Analysis DNA biology.organism_classification Virology Vaccination 030104 developmental biology Infectious Diseases Viral Fusion Proteins |
| Zdroj: | Microbial Pathogenesis. 99:83-86 |
| ISSN: | 0882-4010 |
| Popis: | Newcastle disease virus (NDV) is the causative agent of Newcastle disease (ND) in many avian species. ND is a serious problem in developing countries, causing huge loss in the poultry industry. Although there are reports of continuous outbreaks of ND leading to serious losses to the poultry farming, very less is known about the genetic characteristics of its strains circulating in different parts of India. In the present study, we have five isolates of NDV reported from different outbreaks in Central India between the years 2006-2012. Deduced amino acid sequence of the F protein cleavage site and phylogenetic analysis of all the five isolates showed circulation of NDV genotype XIIIb. All the isolates showed a unique virulent cleavage site 112RRQKR↓F117. The close genetic similarity of all the isolates suggested circulation of the virulent NDV strains of the same ancestor in and around central India. Continuous isolation of genotype XIIIb NDV strains within the country suggests its panzootic potential. The study will be useful to understand the circulating strains of NDV and plan a vaccination strategy for poultry in India. |
| Databáze: | OpenAIRE |
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