Determination of Iron Absorption from Whole Diet: A New Two-Pool Model Using Two Radioiron Isotopes Given as Haem and Non-Haem Iron
| Autor: | Erik Björn-Rasmussen, Leif Hallberg |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Absorption (pharmacology) Whole body counting Isotope Chemistry Iron Iron absorption digestive oral and skin physiology Inorganic chemistry Non haem iron Radiochemistry Blood Donors Heme Hematology Iron Isotopes Models Biological Diet Hemoglobins chemistry.chemical_compound TRACER Methods Humans Hemoglobin |
| Zdroj: | Scandinavian Journal of Haematology. 9:193-197 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1972.tb00930.x |
| Popis: | Preliminary data strongly indicate that there is a complete isotopic exchange between an added inorganic iron tracer and non-haem iron compounds in a number of foodstuffs when thoroughly mixed with the food during preparation. The absorption of such a tracer is expected to give a true measure of the total absorption of non-haem iron from the diet. Similarly there is evidence indicating that radioiron-labeled hemogiobin may be used as a tracer for studies on haem iron absorption from the diet. A two-pool model is suggested for food iron absorption---one haem iron and one non-haem iron pool. These pools can be independently labeled with an inorganic radioiron tracer and with radioiron- labeled hemoglobin by using two different radioiron isotopes. The total absorption of iron from these pools (from the whole diet) can be measured from the combined measurement of total body retention of /sup 59/Fe using whole body counting and determination of the ratio /sup 55/Fe//sup 59/Fe in a blood sample. A report of preliminary studies on the application of this method in normal and iron deficient men is also given. (auth) |
| Databáze: | OpenAIRE |
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