The changing epidemiology of liver diseases in the Asia-Pacific region
| Autor: | Henry Lik-Yuen Chan, Jacob George, Martin C.S. Wong, Junjie Huang, Siew C. Ng, Mohammed Eslam, Colette Leung, Jason L W Huang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cirrhosis Asia Hepatitis C virus medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Environmental health Nonalcoholic fatty liver disease Epidemiology Medicine Humans Liver Diseases Alcoholic Disease burden Hepatitis B virus Hepatology business.industry Coinfection Asia Eastern Liver Diseases Gastroenterology medicine.disease Hepatitis B Hepatitis C Epidemiological transition 030104 developmental biology 030211 gastroenterology & hepatology Chemical and Drug Induced Liver Injury business Liver cancer |
| Zdroj: | Nature reviews. Gastroenterologyhepatology. 16(1) |
| ISSN: | 1759-5053 |
| Popis: | This Review presents current epidemiological trends of the most common liver diseases in Asia–Pacific countries. Hepatitis B virus (HBV) remains the primary cause of cirrhosis; despite declining prevalence in most Asian nations, this virus still poses a severe threat in some territories and regions. Mortality resulting from HBV infection is declining as a result of preventive measures and antiviral treatments. The epidemiological transition of hepatitis C virus (HCV) infection has varied in the region in the past few decades, but the medical burden of infection and the prevalence of its related cancers are increasing. The lack of licensed HCV vaccines highlights the need for novel treatment strategies. The prevalence of nonalcoholic fatty liver disease (NAFLD) has risen in the past decade, mostly owing to increasingly urbanized lifestyles and dietary changes. Alternative herbal medicine and dietary supplements are major causes of drug-induced liver injury (DILI) in some countries. Complications arising from these chronic liver diseases, including cirrhosis and liver cancer, are therefore emerging threats in the Asia–Pacific region. Key strategies to control these liver diseases include monitoring of at-risk populations, implementation of national guidelines and increasing public and physician awareness, in concert with improving access to health care. Liver diseases exert a substantial disease burden across the Asia–Pacific region. In this Review, the authors explore the epidemiological trends in the most common liver diseases in the region, including HBV infection, HCV infection and nonalcoholic fatty liver disease, and discuss implications for preventive measures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink