Male HIV-1 transgenic rats show reduced cocaine-maintained lever-pressing compared to F344 wildtype rats despite similar baseline locomotion
| Autor: | Jennifer E. Murray, Shilpa Buch, Y. Wendy Huynh, Minglei Guo, Rick A. Bevins, Brady M. Thompson, Christopher E. Larsen |
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| Rok vydání: | 2019 |
| Předmět: |
Male
050103 clinical psychology medicine.medical_specialty AIDS Dementia Complex Rat model Human immunodeficiency virus (HIV) Experimental and Cognitive Psychology medicine.disease_cause Locomotor activity Article Behavioral Neuroscience Cocaine-Related Disorders Internal medicine medicine Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology business.industry 05 social sciences Wild type Rats Inbred F344 Rats Endocrinology HIV-1 Conditioning Operant Lever pressing Substance use Rats Transgenic Self-administration business Transgenic Rats Locomotion |
| Zdroj: | J Exp Anal Behav |
| ISSN: | 1938-3711 |
| Popis: | The HIV-1 transgenic (Tg) rat model is valuable for understanding HIV-associated neurocognitive disorders (HAND) and accompanying substance use and misuse. Tg and F344/NHsd wildtype (WT) rats were allowed to self-administer intrajugular cocaine. For the first seven sessions, neither genotype self-administered cocaine (0.1 mg/kg/infusion) on a fixed ratio 1 schedule. We thus implemented a lever–cocaine “autoshaping” session followed by a series of manipulations changing dose and reinforcement schedule. Tg rats self-administered much less cocaine than WT rats throughout the study. Five of eight Tg rats modestly increased self-administration from sessions 36–50. Of those, only three showed a lever discrimination. Eight of ten WT rats acquired robust self-administration by session 19; all WT rats self-administered cocaine by the end of the study. WT and Tg rats had similar baseline locomotor activity in the self-administration chamber suggesting that the low levels of cocaine intake in the Tg rats did not reflect a non-specific motor impairment in this rat strain. Concomitant measurement of activity with self-administration revealed activity increases that followed increased cocaine intake. That relation held in Tg rats. Therefore, the present study provides evidence that HIV-1 Tg rats are less sensitive to the reinforcing effects of cocaine than their F344 WT counterparts. |
| Databáze: | OpenAIRE |
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