The Value of MiR-383, an Intronic MiRNA, as a Diagnostic and Prognostic Biomarker in Intestinal-Type Gastric Cancer
| Autor: | Reza Safaralizadeh, Shirin Azarbarzin, Alavieh Fateh, Mina Kazemzadeh, Mohammad Ali Hosseinpour Feizi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Genetic enhancement Adenocarcinoma Biology Bioinformatics medicine.disease_cause Biochemistry 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Stomach Neoplasms Intestinal Neoplasms microRNA Gene expression Biomarkers Tumor Genetics medicine Humans Molecular Biology Ecology Evolution Behavior and Systematics Tumor marker Cancer General Medicine Middle Aged Prognosis medicine.disease Introns Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Real-time polymerase chain reaction Case-Control Studies 030220 oncology & carcinogenesis Cancer research Female Neoplasm Grading Carcinogenesis |
| Zdroj: | Biochemical Genetics. 55:244-252 |
| ISSN: | 1573-4927 0006-2928 |
| Popis: | MicroRNAs, a class of gene expression regulatory non-coding RNAs, participate in the pathogenic mechanisms of gastric cancer which is one of the life-treating cancers. Due to its aberrant expression in some types of human cancer, miR-383 has the value of being investigated in relation to cancer treatment and diagnosis. MiR-383 is placed in intron of SGCZ, a protein-coding gene, which is subject to dysregulation in various diseases. The purpose of the current study was to investigate the contribution of miR-383 to intestinal-type gastric adenocarcinoma tumorigenesis. The expression level of miR-383 was investigated by qRT-PCR in pairs of tumorous and adjacent tumor-free tissues of 40 patients with gastric cancer during endoscopy. Also, the susceptibility of miR-383 as a tumor marker and the relationship between its aberrant expression and clinicopathological features were determined. qRT-PCR data showed that miR-383 was dysregulated during gastric tumorigenesis. MiR-383 was dramatically downregulated up to sevenfold in intestinal-type gastric adenocarcinoma compared with adjacent tumor-free tissues (P |
| Databáze: | OpenAIRE |
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