Evaluation of the efficacy of emodepside+praziquantel topical solution against cestode (Dipylidium caninum, Taenia taeniaeformis, and Echinococcus multilocularis) infections in cats
| Autor: | J. Buch, Terry Settje, Eberhard Schein, Gertraut Altreuther, K R Kazacos, Samuel Charles, Dwight D. Bowman, Dawid J. Kok, L. Cruthers, C. R. Reinemeyer, David Jenkins |
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| Rok vydání: | 2005 |
| Předmět: |
Veterinary medicine
Administration Topical Taenia taeniaeformis Pharmacology Cat Diseases Echinococcus multilocularis Praziquantel Efficacy Depsipeptides parasitic diseases medicine Animals Anthelmintic Dipylidium caninum Anthelmintics CATS Dose-Response Relationship Drug General Veterinary biology General Medicine Cestode Infections biology.organism_classification Infectious Diseases Insect Science Cats Cestoda Drug Therapy Combination Parasitology Emodepside medicine.drug |
| Zdroj: | Parasitology Research. 97:S33-S40 |
| ISSN: | 1432-1955 0932-0113 |
| DOI: | 10.1007/s00436-005-1442-3 |
| Popis: | Emodepside+praziquantel topical solution was developed to provide broad–spectrum anthelmintic activity against gastrointestinal parasites in cats. Eight controlled studies were conducted to evaluate the efficacy of a topical solution of emodepside (3 mg/kg) and praziquantel (12 mg/kg) (Profender®, BayerAG, Leverkusen, Germany) against feline infections with three species of cestodes. Studies featured naturally acquired infections of Dipylidium caninum or Taenia taeniaeformis, or experimental infections with Echinococcus multilocularis that were placebo–controlled, randomized and blinded. Cats were euthanatized and necropsied between 2 and 11 days after treatment, depending on the target parasite. The efficacy of emodepside+praziquantel topical solution was 100% against D. caninum and T. taeniaeformis, and 98.5– 100% against E. multilocularis. No significant systemic or local adverse reactions to treatment were noted in cats that received the combination. Topical treatment of cats with emodepside+praziquantel topical solution was safe and highly effective against cestode infections. |
| Databáze: | OpenAIRE |
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