Quality of life in patients with familial amyloidotic polyneuropathy long-term after liver transplantation
| Autor: | Elizabeth B. Haagsma, Gerda Drent, Bouke P. C. Hazenberg, Cornelia W. Graveland |
|---|---|
| Přispěvatelé: | Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics congenital hereditary and neonatal diseases and abnormalities SF-36 Adolescent medicine.medical_treatment Health Status Disease Liver transplantation Transthyretin DISEASE Polyneuropathies Young Adult Quality of life orthotopic liver transplantation Surveys and Questionnaires Internal Medicine medicine Humans Young adult neoplasms Aged Amyloid Neuropathies Familial business.industry Amyloidosis FAP HEALTH SURVEY Middle Aged medicine.disease digestive system diseases Surgery Liver Transplantation SINGLE-CENTER EXPERIENCE Transplantation RECIPIENTS Treatment Outcome quality of life Disease Progression SURVIVAL Female business FOLLOW-UP Polyneuropathy inherited amyloidosis |
| Zdroj: | Amyloid: Journal of protein folding disorders, 16(3), 133-141. Taylor & Francis Ltd |
| ISSN: | 1350-6129 |
| Popis: | Liver transplantation aims to halt the progression of the disease in patients with familial amyloidotic polyneuropathy (FAP) caused by hereditary transthyretin-related (ATTR) amyloidosis. Insight in health-related quality of life of these transplanted FAP-patients can be of help to optimize health care delivery. The aim of this cross-sectional study was to assess the health-related quality of life of patients with FAP long-term after transplantation.Nine patients with a post-transplant follow-up of 4 years or more were included in the study. During the annual checks, health-related quality of life was measured with the Short Form-36 (SF-36). Data were compared with non-FAP transplanted patients with the same duration of follow-up and with the normal Dutch population. Pre-transplant, all patients had signs of mild to moderate peripheral polyneuropathy.The results showed that in patients with FAP health-related quality of life was stable in the first 4 years after transplantation. The domain of physical well-being at 4 years after transplantation was significantly lower compared to non-FAP transplanted patients and control Dutch population. The domain of emotional well-being was comparable with non-FAP controls. However, on most health areas patients with FAP scored lower than the non-FAP transplanted patients and the Dutch controls. After four years, the three patients with FAP with longest follow-up (9-12 years) deteriorated in all health domains, except in self-perceived mental health.This study, including only a small number of patients with FAP, shows a relatively low health-related quality of life after liver transplantation, which may deteriorate further with longer follow-up. |
| Databáze: | OpenAIRE |
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