Phenotypes of Severe Cutaneous Adverse Reactions Caused by Nonsteroidal Anti-inflammatory Drugs
| Autor: | Young Min Ye, Joo-Hee Kim, Min Seok Yang, Min Gyu Kang, Young Il Koh, Sujeong Kim, Jun Gyu Lee, Hyen Oh La, Sae Hoon Kim, Suh Young Lee, Jae Woo Jung, Min Hye Kim, Yi Yeong Jeong, Seong Ju Park, Hye Ryun Kang, Chan Sun Park, Jung Won Park, Gyu Young Hur, Sang-Heon Kim, Hye-Kyung Park, Yong Eun Kwon, Sang Hyon Kim, Young Koo Jee, Young-Hee Nam, Jin Yong Lee, Hyun Jung Jin, Mi Yeong Kim, Cheol Woo Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty medicine.drug_class Immunology Scars Anti-inflammatory Drug Hypersensitivity 03 medical and health sciences 0302 clinical medicine Pharmacotherapy medicine Immunology and Allergy 030223 otorhinolaryngology Adverse effect Prospective cohort study business.industry Anti-Inflammatory Agents Non-Steroidal Overlap syndrome medicine.disease Dermatology Toxic epidermal necrolysis Acetaminophen stomatognathic diseases 030228 respiratory system Stevens-Johnson Syndrome Original Article medicine.symptom business medicine.drug |
| Zdroj: | Allergy, Asthma & Immunology Research |
| ISSN: | 2092-7363 2092-7355 |
| Popis: | Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) are common cause of severe cutaneous adverse reactions (SCARs). The present study aimed to investigate the characteristics of SCARs induced by NSAIDs in the Korean SCAR registry. Methods A retrospective survey of NSAID-induced SCARs recorded between 2010 and 2015 at 27 university hospitals in Korea was conducted. Clinical phenotypes of SCARs were classified into Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), SJS-TEN overlap syndrome and drug reaction with eosinophilia and systemic symptoms (DRESS). Causative NSAIDs were classified into 7 groups according to their chemical properties: acetaminophen, and propionic, acetic, salicylic, fenamic and enolic acids. Results A total of 170 SCARs, consisting of 85 SJS, 32 TEN, 17 SJS-TEN overlap syndrome and 36 DRESS reactions, were induced by NSAIDs: propionic acids (n=68), acetaminophen (n=38), acetic acids (n=23), salicylic acids (n=16), coxibs (n=8), fenamic acids (n=7), enolic acids (n=5) and unclassified (n=5). Acetic acids (22%) and coxibs (14%) accounted for higher portions of DRESS than other SCARs. The phenotypes of SCARs induced by both propionic and salicylic acids were similar (SJS, TEN and DRESS, in order). Acetaminophen was primarily associated with SJS (27%) and was less involved in TEN (10%). DRESS occurred more readily among subjects experiencing coxib-induced SCARs than other NSAID-induced SCARs (62.5% vs. 19.7%, P = 0.013). The mean time to symptom onset was longer in DRESS than in SJS or TEN (19.1 ± 4.1 vs. 6.8 ±1.5 vs. 12.1 ± 3.8 days). SCARs caused by propionic salicylic acids showed longer latency, whereas acetaminophen- and acetic acid-induced SCARs appeared within shorter intervals. Conclusions The present study indicates that the phenotypes of SCARs may differ according to the chemical classifications of NSAIDs. To establish the mechanisms and incidences of NSAID-induced SCARs, further prospective studies are needed. |
| Databáze: | OpenAIRE |
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