Involvement of the serotonergic type 1A (5-HT 1A ) receptor in the agranular insular cortex in the consolidation of memory for inhibitory avoidance in rats
| Autor: | Ivan Antonio Izquierdo, A Coitinho, Elsa Regina do Canto Vinade, Márcia Maria de Souza, T Mello e Souza, Humberto Kukhyun Choi, Cleverson Rodrigues |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Prefrontal Cortex Amnesia Insular cortex Serotonergic Piperazines Injections Memory Internal medicine Avoidance Learning medicine Animals Rats Wistar Prefrontal cortex Pharmacology 8-Hydroxy-2-(di-n-propylamino)tetralin business.industry Receptor antagonist Rats Serotonin Receptor Agonists Psychiatry and Mental health Endocrinology nervous system Receptors Serotonin 5-HT1A receptor Memory consolidation Serotonin Antagonists medicine.symptom business Receptors Serotonin 5-HT1 Neuroscience |
| Zdroj: | Behavioral Pharmacology. 12:349-353 |
| ISSN: | 0955-8810 |
| Popis: | Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the agranular insular cortex of the prefrontal cortex. After recovery, animals were trained in a step-down inhibitory avoidance task (3.0-s, 0.4-mA footshock) and received, immediately after training, a 0.5-microl infusion of the serotonergic type 1A (5-HT1A) receptor agonist dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide (8-OH-DPAT) or of the 5- HT1A receptor antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (NAN-190), or of vehicle alone (20% DMSO). Retention testing was carried out 24 h after training. 8-OH-DPAT (1.25 and 6.25 microg but not 0.0125 or 0.125 microg) was amnesic. NAN-190 was not effective at 0.125 or 1.25 microg any dose but reversed amnesia when given at 1.250 microg simultaneously with both effective doses of 8-OH-DPAT. These results show that an overactivation of 5-HT1A receptors in the agranular insular cortex impairs memory consolidation of inhibitory avoidance, in rats, immediately after training. This suggests that these receptors of the insular cortex may modulate memory consolidation. |
| Databáze: | OpenAIRE |
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