Magnesium taurate attenuates progression of hypertension and cardiotoxicity against cadmium chloride-induced hypertensive albino rats
| Autor: | Rajesh Choudhary, Jaya Shree, Parikshit Shrivastava, Surendra H. Bodakhe, Prabhat Kumar Vishwakarma, Amrita Singh, Umashankar Nirmalkar |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment lcsh:Medicine 030204 cardiovascular system & hematology Pharmacology Cadmium chloride 03 medical and health sciences chemistry.chemical_compound Magnesium taurate 0302 clinical medicine Medicine Amlodipine chemistry.chemical_classification Cardiotoxicity business.industry Glutathione peroxidase lcsh:R Glutathione Malondialdehyde 030104 developmental biology Blood pressure Complementary and alternative medicine chemistry Hypertension Original Article business medicine.drug |
| Zdroj: | Journal of Traditional and Complementary Medicine, Vol 9, Iss 2, Pp 119-123 (2019) Journal of Traditional and Complementary Medicine |
| ISSN: | 2225-4110 |
| Popis: | The present study was designed to evaluate the antihypertensive activity and cardioprotective effects of magnesium taurate against cadmium chloride (CdCl2)-intoxicated albino rats. Sprague Dawley male albino rats (120–150 g) were divided into five groups having six animals in each group. Hypertension and cardiotoxicity were induced in animals by administration of CdCl2 (0.5 mg/kg/day, i.p.) for four weeks. Magnesium taurate (2 and 4 mg/kg/day) was administered orally after induction of hypertension (after two weeks) in their respective groups concurrently with CdCl2 for next two weeks. Amlodipine (3 mg/kg/day, p.o.) was used as a standard and administered after induction of hypertension. Blood pressure was monitored biweekly by using non-invasive blood pressure system and biochemical parameters and histopathology of the heart were evaluated after four weeks of the experimental protocol. During the four weeks of the experimental protocol, the toxic control group showed significant elevation of systolic and diastolic blood pressure concomitant with augmentation of cardiotoxicity as indicated by reduction in myocardial antioxidants including glutathione peroxidase, catalase, superoxide dismutase, reduced glutathione and increased malondialdehyde level in heart as compared to the normal group. The oral administrations of magnesium taurate significantly restored the blood pressure, myocardial antioxidants and malondialdehyde level as compared to toxic control group. In addition, histopathological examination showed that magnesium taurate treatments substantially reduced the myocardial damages against CdCl2 treatment. The results suggest that magnesium taurate has prominent antihypertensive and cardioprotective activity via its potent antioxidant activity and can be used as a nutrition supplement to improve the cardiovascular health. Graphical abstract Image 1 |
| Databáze: | OpenAIRE |
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