Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells
| Autor: | Nicholas J. Maness, Oluwasayo Akinyosoye, Andrea M. Weiler, Jason S. Reed, Thomas C. Friedrich, Antonito T. Panganiban, Jonah B. Sacha, Arpita Das, Eva G. Rakasz, Shelby L. O’Connor, Elizabeth A. Scheef, Sherry Cui |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
viruses Immunology Mutation Missense Epitopes T-Lymphocyte CD8-Positive T-Lymphocytes medicine.disease_cause Major histocompatibility complex Microbiology Epitope Virus 03 medical and health sciences 0302 clinical medicine Virology medicine Animals Viral Regulatory and Accessory Proteins Viral Sequencing biology Histocompatibility Antigens Class I virus diseases High-Throughput Nucleotide Sequencing Simian immunodeficiency virus biology.organism_classification Virus-Cell Interactions 030104 developmental biology Insect Science Lentivirus biology.protein Macaca CD8 030215 immunology |
| Popis: | Nef-specific CD8 + T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B*017:01-restricted Nef 165–173 IW9 epitope revealed highly restricted evolution. A common acute escape variant, T 170 I, unexpectedly and uniquely degraded Nef's major histocompatibility complex class I (MHC-I) downregulatory capacity, rendering the virus more vulnerable to CD8TL targeting other epitopes. These data aid in a mechanistic understanding of Nef functions and suggest means of immunity-mediated control of lentivirus replication. |
| Databáze: | OpenAIRE |
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