Association of low serum Meteorin like (Metrnl) concentrations with worsening of glucose tolerance, impaired endothelial function and atherosclerosis

Autor: Fayrouz Othman Selim, Hazem M. El-Ashmawy, Hosam Nabil Almassry, Thoraya A.M. Hosny
Rok vydání: 2018
Předmět:
Blood Glucose
Male
Endocrinology
Diabetes and Metabolism
Type 2 diabetes
Carotid Intima-Media Thickness
0302 clinical medicine
Endocrinology
Risk Factors
Glucose homeostasis
030212 general & internal medicine
Endothelial dysfunction
General Medicine
Middle Aged
Intercellular Adhesion Molecule-1
C-Reactive Protein
Egypt
Female
E-Selectin
Adult
medicine.medical_specialty
Vascular Cell Adhesion Molecule-1
030209 endocrinology & metabolism
Pulse Wave Analysis
Proinflammatory cytokine
03 medical and health sciences
Young Adult
Insulin resistance
Adipokines
Diabetes mellitus
Internal medicine
Glucose Intolerance
Internal Medicine
medicine
Humans
Ankle Brachial Index
Risk factor
Aged
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
medicine.disease
Atherosclerosis
Cross-Sectional Studies
Diabetes Mellitus
Type 2
Endothelium
Vascular
Insulin Resistance
business
Homeostasis
Biomarkers
Zdroj: Diabetes research and clinical practice. 150
ISSN: 1872-8227
Popis: Meteorin-like (Metrnl) is a novel secreted protein that has a beneficial effect on glucose homeostasis with anti-inflammatory properties. Our goal is to determine whether low serum Metrnl levels are associated with worsening of glucose tolerance, impaired endothelial function, and atherosclerosis.This study included 260 adults, 89 of whom had normal oral glucose tolerance (nOGT), 77 with glucose tolerance impairment (GTI) and 94 with type 2 diabetes (T2DM). Insulin resistance was assessed by evaluating the homeostasis model assessment of insulin resistance (HOMA-IR). Serum Metrnl level, proinflammatory, biochemical, endothelial and atherosclerosis parameters were measured.Serum Metrnl levels decreased significantly in patients with T2DM versus subjects with nOGT (P 0.001). Metrnl levels were negatively correlated with fasting blood glucose, 2-h postload glucose (2 h-PLG), fasting insulin, HOMA-IR, HbA1c, high-sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), Carotid intima media thickness (CIMT), brachial-ankle pulse wave velocity (baPWV), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin. High serum Metrnl level was significantly correlated with reduced risk of T2DM as revealed by multivariate logistic regression analysis after control of potential risk factors for diabetes. Furthermore, the association remains significant after further adjustment for IL-6, TNF-α, hs-CRP, CIMT, baPWV, ICAM-1, VCAM-1 and E-selectin.Low Serum Metrnl may be associated with worsening of glucose tolerance, impaired endothelial function and atherosclerosis. It may also be considered a possible surrogate marker of endothelial dysfunction, and atherosclerosis and an independent risk factor of T2DM.
Databáze: OpenAIRE
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