Urinary MHPG excretion in minimal brain dysfunction and its modification by d-amphetamine
| Autor: | Walid O. Shekim, Haroutune Dekirmenjian, James L. Chapel |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Drug
Male medicine.medical_specialty Dextroamphetamine Urinary system media_common.quotation_subject Hyperkinesis Methoxyhydroxyphenylglycol Excretion Norepinephrine (medication) Glycols Pharmacotherapy Internal medicine medicine Humans Amphetamine Child media_common business.industry Psychiatry and Mental health Endocrinology Attention Deficit Disorder with Hyperactivity business medicine.drug |
| Zdroj: | The American journal of psychiatry. 136(5) |
| ISSN: | 0002-953X |
| Popis: | The authors studied the excretion of 3-methoxy-4-hydroxyphenlyglycol (MHPG) in 15 hyperactive boys and 13 controls. They further examined soft neurologic signs and clinical drug response to d-amphetamine administration for two weeks in the hyperactive boys. MHPG excretion was significantly lower in the hyperactive boys than in the controls. d-Amphetamine decreased MHPG excretion significantly in the drug responders only. Pretreatment MHPG excretion did not predict clinical drug response. The responders had more soft neurologic signs than the nonresponders. Furthermore, soft neurologic signs were not related to pretreatment MHPG levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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