Beta-lactam resistance mechanisms in pathogens isolated from patients admitted to intensive care unit
| Autor: | Mirela Voicu, Delia Muntean, Ovidiu Horea Bedreag, Victor Dumitrascu, Dorina Dugaesescu, Florin George Horhat, Carmen Axente, Elena Hogea, Roxana Moldovan, Dorel Sandesc, Monica Licker, Luminita Baditoiu |
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| Předmět: |
medicine.medical_specialty
business.industry Materials Science (miscellaneous) Process Chemistry and Technology General Engineering General Chemistry General Medicine Intensive care unit General Biochemistry Genetics and Molecular Biology law.invention Beta-lactam chemistry.chemical_compound chemistry law Internal medicine Materials Chemistry Medicine General Pharmacology Toxicology and Pharmaceutics business |
| Zdroj: | Scopus-Elsevier |
| Popis: | Intensive care units (ICUs) are often referred to as the epicentre of infection diseases in a hospital. Many studies highlighted the importance of using local antimicrobial resistance data, to guide empirical antibiotic therapy. As a consequence, the present study is particularly important, especially in the current context, when we are witnessing an ascending trend of antimicrobial resistance. Beta-lactams are the most frequently used class of antibiotics for treating patients infected with various germs. The aim of this study is to analyse the modalities by which microorganisms become resistant to antibiotics of this class, in an intensive care unit of a Romanian university hospital. During the period between January, the 1st 2012 and December the 31st 2013, a prospective study was conducted in the largest ICU from the Western part of Romania. Various resistance mechanisms to beta-lactam antibiotics were detected. Among these, there is great concern regarding the high number of extended-spectrum beta-lactamase producing microorganisms, as in most cases they determine the use of carbapenems, thus increasing the risk of occurrence and dissemination of carbapenemase-producing bacteria. |
| Databáze: | OpenAIRE |
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