Peripheral blood gene expression signatures which reflect smoking and aspirin exposure are associated with cardiovascular events
| Autor: | Brian Kent Rhees, Karen Fitch, James A. Wingrove, Deepak Voora, Steven A. Rosenberg |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine lcsh:Internal medicine medicine.medical_specialty lcsh:QH426-470 Platelet Aggregation Disease 030204 cardiovascular system & hematology Logistic regression Cardiovascular events 03 medical and health sciences 0302 clinical medicine Internal medicine Gene expression Genetics medicine Humans cardiovascular diseases Myocardial infarction lcsh:RC31-1245 Stroke Genetics (clinical) Aged Aspirin business.industry Smoking Odds ratio Aspirin exposure Middle Aged medicine.disease lcsh:Genetics 030104 developmental biology Cardiovascular Diseases Female Transcriptome business Mace Research Article medicine.drug |
| Zdroj: | BMC Medical Genomics BMC Medical Genomics, Vol 11, Iss 1, Pp 1-9 (2018) |
| ISSN: | 1755-8794 |
| DOI: | 10.1186/s12920-017-0318-6 |
| Popis: | Background Cardiovascular disease and its sequelae are major causes of global mortality, and better methods are needed to identify patients at risk for future cardiovascular events. Gene expression analysis can inform on the molecular underpinnings of risk factors for cardiovascular events. Smoking and aspirin have known opposing effects on platelet reactivity and MACE, however their effects on each other and on MACE are not well described. Methods We measured peripheral blood gene expression levels of ITGA2B, which is upregulated by aspirin and correlates with platelet reactivity on aspirin, and a 5 gene validated smoking gene expression score (sGES) where higher expression correlates with smoking status, in participants from the previously reported PREDICT trial (NCT 00500617). The primary outcome was a composite of death, myocardial infarction, and stroke/TIA (MACE). We tested whether selected genes were associated with MACE risk using logistic regression. Results Gene expression levels were determined in 1581 subjects (50.5% female, mean age 60.66 +/−11.46, 18% self-reported smokers); 3.5% of subjects experienced MACE over 12 months follow-up. Elevated sGES and ITGA2B expression were each associated with MACE (odds ratios [OR] =1.16 [95% CI 1.10–1.31] and 1.42 [95% CI 1.00–1.97], respectively; p |
| Databáze: | OpenAIRE |
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