Loss of interleukin-21 leads to atrophic germinal centers in multicentric Castleman’s disease
| Autor: | Kohzoh Imai, Hidetaka Yajima, Yui Shimizu, Motohisa Yamamoto, Yasuhisa Shinomura, Hiroki Takahashi, Yasuyoshi Naishiro, Nodoka Sakurai, Chisako Suzuki |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pathology 03 medical and health sciences Interleukin 21 0302 clinical medicine Internal medicine medicine Humans B-cell lymphoma Microdissection Aged 030203 arthritis & rheumatology Hematology biology business.industry Castleman Disease Interleukins Hypergammaglobulinemia nutritional and metabolic diseases Interleukin Germinal center General Medicine Middle Aged Germinal Center medicine.disease eye diseases 030104 developmental biology Immunology biology.protein Female Atrophy Antibody business |
| Zdroj: | Annals of Hematology. 95:35-40 |
| ISSN: | 1432-0584 0939-5555 |
| Popis: | Both multicentric Castleman's disease (MCD) and immunoglobulin (Ig)G4-related disease (IgG4-RD) are systemic diseases, presenting with hypergammaglobulinemia and elevated serum levels of IgG4. However, with regard to histopathological findings, MCD shows atrophic germinal centers. On the other hand, expanded germinal centers are detected in IgG4-RD. We extracted germinal centers from specimens of each disorder by microdissection and analyzed the expression of mRNAs by real-time polymerase chain reaction to clarify the mechanisms underlying atrophied germinal centers in MCD. This analysis disclosed loss of interleukin (IL)-21 and B cell lymphoma (Bcl)-6 in the germinal centers of MCD. Loss of IL-21 is considered to be involved in the disappearance of Bcl-6 and leads to atrophied germinal centers in MCD. |
| Databáze: | OpenAIRE |
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