Respiratory hypersensitivity reactions to NSAIDs in Europe:the global allergy and asthma network (GA(2) LEN) survey
| Autor: | C Kai-Håkon, Peter H. Howarth, SE Dahlen, Peter Burney, C Louiro, Bertil Forsberg, Torsten Zuberbier, E Salagean, Nikolaos G. Papadopoulos, Bo Lundbäck, J Minov, Lukasz Kasper, Thomas Keil, JE Zejda, Christer Janson, J Bislimovska, Ewa Nizankowska-Mogilnicka, B. Dahlén, Philippe-Jean Bousquet, W. J. Fokkens, Mark Gjomarkaj, Elina Toskala, Grzegorz Brożek, Deborah Jarvis, Jean Bousquet, Claus Bachert, Marek L. Kowalski, Ana Todo-Bom, Joanna Makowska, Carsten Bindslev-Jensen, Jesper Bælum, Peter Tomassen, A. Sakellariou, U Kraemer |
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| Přispěvatelé: | Ear, Nose and Throat |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
Allergy Pediatrics medicine.medical_specialty Cross-sectional study Immunology Population Drug allergy Disease digestive system 03 medical and health sciences 0302 clinical medicine Epidemiology medicine Immunology and Allergy 030212 general & internal medicine skin and connective tissue diseases education Asthma education.field_of_study business.industry Odds ratio medicine.disease Dermatology digestive system diseases 030228 respiratory system business |
| Zdroj: | Makowska, J S, Burney, P, Jarvis, D, Keil, T, Tomassen, P, Bislimovska, J, Brozek, G, Bachert, C, Baelum, J, Bindslev-Jensen, C, Bousquet, J, Bousquet, P J, Kai-Håkon, C, Dahlen, S E, Dahlen, B, Fokkens, W J, Forsberg, B, Gjomarkaj, M, Howarth, P, Salagean, E, Janson, C, Kasper, L, Kraemer, U, Louiro, C, Lundback, B, Minov, J, Nizankowska-Mogilnicka, E, Papadopoulos, N, Sakellariou, A G, Todo-Bom, A, Toskala, E, Zejda, J E, Zuberbier, T & Kowalski, M L 2016, ' Respiratory hypersensitivity reactions to NSAIDs in Europe : the global allergy and asthma network (GA(2) LEN) survey ', Allergy, vol. 71, no. 11, pp. 1603-1611 . https://doi.org/10.1111/all.12941 Allergy, 71(11), 1603-1611. Wiley-Blackwell |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/all.12941 |
| Popis: | BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most prevalent drugs inducing hypersensitivity reactions. The aim of this analysis was to estimate the prevalence of NSAID-induced respiratory symptoms in population across Europe and to assess its association with upper and lower respiratory tract disorders.METHODS: The GA(2) LEN survey was conducted in 22 centers in 15 European countries. Each of 19 centers selected random samples of 5000 adults aged 15-74 from their general population, and in three centers (Athens, Munich, Oslo), a younger population was sampled. Questionnaires including questions about age, gender, presence of symptoms of asthma, allergic rhinitis, chronic rhinosinusitis, smoking status, and history of NSAID-induced hypersensitivity reactions were sent to participants by mail. Totally, 62 737 participants completed the questionnaires.RESULTS: The mean prevalence of NSAID-induced dyspnea was 1.9% and was highest in the three Polish centers [Katowice (4.9%), Krakow (4.8%), and Lodz (4.4%)] and lowest in Skopje, (0.9%), Amsterdam (1.1%), and Umea (1.2%). In multivariate analysis, the prevalence of respiratory reactions to NSAIDs was higher in participants with chronic rhinosinusitis symptoms (Odds Ratio 2.12; 95%CI 1.78-2.74), asthma symptoms in last 12 months (2.7; 2.18-3.35), hospitalization due to asthma (1.53; 1.22-1.99), and adults vs children (1.53; 1.24-1.89), but was not associated with allergic rhinitis.CONCLUSION: Our study documented significant variation between European countries in the prevalence of NSAID-induced respiratory hypersensitivity reactions, and association with chronic airway diseases, but also with environmental factors. |
| Databáze: | OpenAIRE |
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